In Path of Exile 2, itemization remains one of the deepest and most rewarding aspects of gameplay. With the introduction of new systems, adjusted drop rates, and evolving meta priorities, knowing which items to keep—or even actively seek—can significantly boost your progression and profit potential.

Whether you're starting fresh, managing multiple poe 2 accounts, or just exploring the economy, here are 18 of the most valuable item types in poe 2 that you should never overlook.

1. Six-Link Items (Even with Bad Mods)

A six-link is always valuable—regardless of base type. Use it for crafting, selling, or upgrading a secondary build. It’s often a consistent currency source in early league days.

2. High-Item-Level Bases

Bases with item level 86 or higher are required for crafting top-tier affixes. This applies especially to gloves, helmets, and boots with powerful influence or eldritch implicits.

3. Influenced Rare Gear

Rare items with Shaper, Elder, Crusader, or Redeemer influence unlock unique modifiers that can’t be rolled otherwise. Even seemingly mediocre gear can be worth a lot if it has the right influence combo.

4. Cluster Jewels

Cluster Jewels are back in poe 2 and continue to enable build-defining passive setups. Large clusters with notable combinations like “Renewal” or “Feed the Fury” are always in demand.

5. Level 21 Skill Gems

Skill gems with level 21 (or level 23 for supports) are highly sought-after for min-maxing. Vaal versions of popular skills, like Vaal Arc or Vaal Skeletons, are especially valuable.

6. High-Quality Flasks

Experimented flasks with increased effect, duration, or unique modifiers are vital for both defense and utility. Flask crafting remains a strong niche for poe 2 accounts focused on endgame optimization.

7. Corrupted Blood Immunity Jewels

Corrupted Blood remains one of the deadliest ailments in the game. A jewel with this immunity, even with weak other mods, is nearly mandatory for most builds.

8. Mana Reservation Efficiency Gear

Helmets or amulets with reservation efficiency mods allow you to run additional auras. This is critical in aura-stacking builds and often drives the market early in leagues.

9. Build-Enabling Uniques

Uniques like Heatshiver, The Covenant, The Squire, and Ashes of the Stars continue to shape powerful builds. When you drop one, check its current meta viability before vendoring.

10. Synthesis Implicit Items

Synthesis bases with valuable implicits like “% increased aura effect” or “chance to avoid elemental ailments” are rare and often worth multiple Divine Orbs when well-rolled.

11. Fractured Items

Fractured mods are the backbone of deterministic crafting. Items with fractured resistances, life, or tier 1 damage stats are perfect targets for Essences and Harvest.

12. Delirium Orbs

Delirium orbs that apply to popular map layouts (like Dunes, Strand, or Cemetery) are always in demand. Many poe 2 accounts stockpile them for bulk farming sessions.

13. Eldritch Embers and Ichors

Crafting with searing exarch and eater of worlds modifiers opens up extremely powerful prefixes and suffixes. Don’t ignore these if they drop, even in small quantities.

14. Scarab Sets

Scarab bundles for Legion, Breach, and Delirium are valuable trade commodities. Players often buy these in bulk to optimize mapping sessions and maximize returns.

15. Sextants with Valuable Mods

Sextants that modify map behavior—such as “adds a shrine,” “maps have a mirrored copy,” or “beyond portals”—can drastically increase profit per map. Use or sell them depending on your strategy.

16. Unique Maps

Maps like Mao Kun, Doryani's Machinarium, or The Coward's Trial often tie into challenges or unique loot. Keep a tab for them, especially if you manage multiple poe 2 accounts with varied goals.

17. Uniques with Good Corruptions

A corrupted Kaom’s Heart with additional resistances or +1 to gems can be game-changing. Use a filter to highlight corrupted uniques—some are worth far more than their clean versions.

18. Mirror-Tier Crafting Bases

Extremely rare, but if you find an item with triple T1 mods, a perfect base type, and open prefixes/suffixes, you might be holding something mirror-worthy. If unsure, always appraise it with trusted trading communities like U4N before deciding.

While not every valuable drop is flashy, recognizing market demand and build potential is key to succeeding in Path of Exile 2. For those browsing poe 2 accounts for sale, checking inventory for these items can reveal hidden value. And for traders and crafters, knowing what to keep can mean the difference between wasting and winning.

As always, communities like U4N are essential for staying up to date with item values, drop rates, and build trends. Whether you're deep in mapping or theorycrafting your next setup, knowing what to pick up is half the battle.